Ontology highlight
ABSTRACT:
SUBMITTER: Stelter S
PROVIDER: S-EPMC6953194 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Stelter Szymon S Paul Mathew J MJ Teh Audrey Y-H AY Grandits Melanie M Altmann Friedrich F Vanier Jessica J Bardor Muriel M Castilho Alexandra A Allen Rachel Louise RL Ma Julian K-C JK
Plant biotechnology journal 20190810 2
Plants can provide a cost-effective and scalable technology for production of therapeutic monoclonal antibodies, with the potential for precise engineering of glycosylation. Glycan structures in the antibody Fc region influence binding properties to Fc receptors, which opens opportunities for modulation of antibody effector functions. To test the impact of glycosylation in detail, on binding to human Fc receptors, different glycovariants of VRC01, a broadly neutralizing HIV monoclonal antibody, ...[more]