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Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes.

ABSTRACT: We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm.

SUBMITTER: Basnet K

PROVIDER: S-EPMC6953408 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes.

Basnet Kanchan K Fatemipouya Tayebeh T St Lorenz Anna A Nguyen Mindy M Taratula Oleh O Henary Maged M Grant Kathryn B KB

Chemical communications (Cambridge, England) 20191001 84

We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm. ...[more]

PMID: 31584046

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