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The relationship between TNF-? gene promoter polymorphism (-?1211 T?>?C), the plasma concentration of TNF-?, and risk of oral mucositis and shortening of overall survival in patients subjected to intensity-modulated radiation therapy due to head and neck cancer.

ABSTRACT: PURPOSE:Radiotherapy (RTH) usually combined with chemotherapy (C-RTH) is the main method of treatment in head and neck cancer (HNC). The most common complication of RTH is oral mucositis (OM). At a certain stage of RTH, it occurs in almost all patients, often lead to discontinuation of treatment. Tumour necrosis factor alpha (TNF-?) is a cytokine secreted during inflammatory process accompanying RTH and the development of cancer itself. Single nucleotide polymorphism (SNP) of the TNF-? promoter region can potentially affect the function or expression of this cytokine, and thus modulate the risk of occurrence and intensity of OM and shortening of overall survival (OS). METHODS:The study group consisted of 62 patients with HNC in whom intensity-modulated radiation therapy (IMRT) technique was applied. The plasma TNF-? level was assessed using the ELISA Kit. Genotyping was performed using a real-time PCR method. RESULTS:HNC patients with the CC genotype of TNF-? (-?1211 T?>?C) have higher TNF-? plasma concentrations than those with T allele (10.70 vs 9.62 ng/ml). Patients with the 3rd degree of OM have significantly higher TNF-? levels after 5th (10.40 vs 9.45 ng/ml) and 7th (10.32 vs 9.60 ng/ml) week of RTH. CC genotype was related to a higher risk of 3rd degree OM development in the last weeks of RTH (5th, OR?=?7.33; 7th, OR?=?23.15). CONCLUSIONS:High TNF-? plasma concentration and CC genotype of TNF-? are related to the higher risk of more severe OM in patients irradiated due to HNC. High TNF-? plasma concentration and CC genotype of TNF-? are independent prognostic factors for patients subjected to RTH due to HNC.

SUBMITTER: Mlak R

PROVIDER: S-EPMC6954128 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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The relationship between TNF-α gene promoter polymorphism (- 1211 T > C), the plasma concentration of TNF-α, and risk of oral mucositis and shortening of overall survival in patients subjected to intensity-modulated radiation therapy due to head and neck cancer.

Mlak Radosław R Powrózek Tomasz T Brzozowska Anna A Homa-Mlak Iwona I Mazurek Marcin M Gołębiowski Paweł P Sobieszek Grzegorz G Małecka-Massalska Teresa T

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20190510 2

<h4>Purpose</h4>Radiotherapy (RTH) usually combined with chemotherapy (C-RTH) is the main method of treatment in head and neck cancer (HNC). The most common complication of RTH is oral mucositis (OM). At a certain stage of RTH, it occurs in almost all patients, often lead to discontinuation of treatment. Tumour necrosis factor alpha (TNF-α) is a cytokine secreted during inflammatory process accompanying RTH and the development of cancer itself. Single nucleotide polymorphism (SNP) of the TNF-α p ...[more]

PMID: 31076897

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Dataset Information

The relationship between TNF-? gene promoter polymorphism (-?1211 T?>?C), the plasma concentration of TNF-?, and risk of oral mucositis and shortening of overall survival in patients subjected to intensity-modulated radiation therapy due to head and neck cancer.

Publications

The relationship between TNF-α gene promoter polymorphism (- 1211 T > C), the plasma concentration of TNF-α, and risk of oral mucositis and shortening of overall survival in patients subjected to intensity-modulated radiation therapy due to head and neck cancer.

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