Ontology highlight
ABSTRACT:
SUBMITTER: Leon K
PROVIDER: S-EPMC6954182 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Leon Katherine K Cunningham Rebecca L RL Riback Joshua A JA Feldman Ezra E Li Jingxian J Sosnick Tobin R TR Zhao Minglei M Monk Kelly R KR Araç Demet D
Nature communications 20200110 1
Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key functions in diverse biological processes including neurodevelopment, embryogenesis, and tumorigenesis. However, their structures and mechanisms of action remain unclear, hampering drug development. The aGPCR Gpr126/Adgrg6 regulates Schwann cell myelination, ear canal formation, and heart development; and GPR126 mutations ...[more]