Ontology highlight
ABSTRACT:
SUBMITTER: Homan KT
PROVIDER: S-EPMC3971390 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Current opinion in cell biology 20131126
The atomic structure of a protein can greatly advance our understanding of molecular recognition and catalysis, properties of fundamental importance in signal transduction. However, a single structure is incapable of fully describing how a protein functions, particularly when allostery is involved. Recent advances in the structure and function of G protein-coupled receptor (GPCR) kinases (GRKs) have concentrated on the mechanism of their inhibition by small and large molecules. These studies hav ...[more]