Dataset Information

Clinical and MRI efficacy of sc IFN ?-1a tiw in patients with relapsing MS appearing to transition to secondary progressive MS: post hoc analyses of PRISMS and SPECTRIMS.

ABSTRACT: This study evaluated efficacy of subcutaneous (sc) interferon beta-1a (IFN ?-1a) 44 µg 3?×?weekly (tiw) in patients appearing to transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS). The PRISMS study included 560 patients with RRMS (EDSS 0-5.0;???2 relapses in previous 2 years), and the SPECTRIMS study included 618 patients with SPMS (EDSS 3.0-6.5 and???1-point increase in previous 2 years [??0.5 point if 6.0-6.5]) randomly assigned to sc IFN ?-1a 44 or 22 µg or placebo for 2-3 years, respectively. These post hoc analyses examined five subgroups of MS patients with EDSS 4.0-6.0: PRISMS (n?=?59), PRISMS/SPECTRIMS (n?=?335), PRISMS/SPECTRIMS with baseline disease activity (n?=?195; patients with either???1 relapse within 2 years before baseline or???1 gadolinium-enhancing lesion at baseline), PRISMS/SPECTRIMS without baseline disease activity (n?=?140), and PRISMS/SPECTRIMS with disease activity during the study (n?=?202). In the PRISMS and PRISMS/SPECTRIMS subgroups, sc IFN ?-1a delayed disability progression, although no significant effect was observed in PRISMS/SPECTRIMS subgroups with activity at baseline or activity during the study (regardless of baseline activity). In the PRISMS/SPECTRIMS subgroup, over year 1 (0-1) and 2 (0-2), sc IFN ?-1a 44 µg tiw significantly reduced annualized relapse rate (p???0.001), and relapse risk (p?

SUBMITTER: Freedman MS

PROVIDER: S-EPMC6954891 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Clinical and MRI efficacy of sc IFN β-1a tiw in patients with relapsing MS appearing to transition to secondary progressive MS: post hoc analyses of PRISMS and SPECTRIMS.

Freedman Mark S MS Brod Staley S Singer Barry A BA Cohen Bruce A BA Hayward Brooke B Dangond Fernando F Coyle Patricia K PK

Journal of neurology 20190926 1

This study evaluated efficacy of subcutaneous (sc) interferon beta-1a (IFN β-1a) 44 µg 3 × weekly (tiw) in patients appearing to transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS). The PRISMS study included 560 patients with RRMS (EDSS 0-5.0; ≥ 2 relapses in previous 2 years), and the SPECTRIMS study included 618 patients with SPMS (EDSS 3.0-6.5 and ≥ 1-point increase in previous 2 years [≥ 0.5 point if 6.0-6.5]) randomly assigned to sc IFN β-1a 44 o ...[more]

PMID: 31559532

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Dataset Information

Clinical and MRI efficacy of sc IFN ?-1a tiw in patients with relapsing MS appearing to transition to secondary progressive MS: post hoc analyses of PRISMS and SPECTRIMS.

Publications

Clinical and MRI efficacy of sc IFN β-1a tiw in patients with relapsing MS appearing to transition to secondary progressive MS: post hoc analyses of PRISMS and SPECTRIMS.

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