Ontology highlight
ABSTRACT:
SUBMITTER: Twelvetrees AE
PROVIDER: S-EPMC6955223 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Twelvetrees Alison E AE Lesept Flavie F Holzbaur Erika L F ELF Kittler Josef T JT
Journal of cell science 20191213 24
Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the kinesin-1 subunit KIF5C <i>in vitro</i> Based upon this co-operative activation of kinesin-1, we propose a modification to the kinesin activation model that incorporates stabilisa ...[more]