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GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program.

ABSTRACT: The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes.

SUBMITTER: Hopkin AS

PROVIDER: S-EPMC3400561 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program.

Hopkin Amelia Soto AS Gordon William W Klein Rachel Herndon RH Espitia Francisco F Daily Kenneth K Zeller Michael M Baldi Pierre P Andersen Bogi B

PLoS genetics 20120719 7

The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent o ...[more]

PMID: 22829784

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