Ontology highlight
ABSTRACT:
SUBMITTER: Ahenkorah S
PROVIDER: S-EPMC6956359 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ahenkorah Stephen S Coertzen Dina D Tong Jie Xin JX Fridianto Kevin K Wittlin Sergio S Birkholtz Lyn-Marie LM Tan Kevin S W KSW Lam Yulin Y Go Mei-Lin ML Haynes Richard K RK
ACS medicinal chemistry letters 20191211 1
Here we report the nanomolar potencies of <i>N</i> <sup>1</sup>,<i>N</i> <sup>3</sup>-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant <i>Plasmodium falciparum</i>. Activity was dependent on the presence of the fused quinone-imidazolium entity and lipophilicity imparted by the N<sup>1</sup>/N<sup>3</sup> alkyl residues on the scaffold. Gametocytocidal activity was also detected, with most members active at IC<sub>50</sub> < 1 μM. A representative analog with good ...[more]