Ontology highlight
ABSTRACT:
SUBMITTER: Zhao M
PROVIDER: S-EPMC6956816 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhao Mengnan M van Straten Demian D Broekman Marike L D MLD Préat Véronique V Schiffelers Raymond M RM
Theranostics 20200101 3
The current achievements in treating glioblastoma (GBM) patients are not sufficient because many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem cells, drug efflux pumps and DNA damage repair mechanisms. Drug combination therapies have shown increasing benefits against those challenges. With the help of nanocarriers, enhancement of the efficacy and safety could be gained using synergistic combinations of different therapeutic agents. In this review, we will di ...[more]