Ontology highlight
ABSTRACT:
SUBMITTER: Shi C
PROVIDER: S-EPMC4499863 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Shi Changying C Guo Dandan D Xiao Kai K Wang Xu X Wang Lili L Luo Juntao J
Nature communications 20150709
The drug-loading properties of nanocarriers depend on the chemical structures and properties of their building blocks. Here we customize telodendrimers (linear dendritic copolymer) to design a nanocarrier with improved in vivo drug delivery characteristics. We do a virtual screen of a library of small molecules to identify the optimal building blocks for precise telodendrimer synthesis using peptide chemistry. With rationally designed telodendrimer architectures, we then optimize the drug-bindin ...[more]