Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.
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ABSTRACT:
SUBMITTER: Lee SM
PROVIDER: S-EPMC6957245 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.
Lee Sang-Min SM Tsai De-Hao DH Hackley Vincent A VA Brechbiel Martin W MW Cook Robert F RF
Nanoscale 20130601 12
We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation. ...[more]
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