Ontology highlight
ABSTRACT:
SUBMITTER: Lownik JC
PROVIDER: S-EPMC6957701 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20191123 2
ADAM17 is known to contribute to the immune system through its shedding of tumor necrosis factor alpha (TNFα). However, the role of ADAM17 in B cell biology is not well characterized. To determine whether B cell ADAM17 contributes to T cell-independent humoral immune responses, we crossed CD19 Cre transgenic mice with mice bearing a floxed allele of ADAM17 (ADAM17<sup>CD19</sup>). In this study, we show a B cell intrinsic role for ADAM17 in regulating marginal zone B cell (MZB) numbers in mice. ...[more]