Ontology highlight
ABSTRACT:
SUBMITTER: Vaeth M
PROVIDER: S-EPMC4917422 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Immunity 20160531 6
T follicular helper (Tfh) cells promote affinity maturation of B cells in germinal centers (GCs), whereas T follicular regulatory (Tfr) cells limit the GC reaction. Store-operated Ca(2+) entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels mediated by STIM and ORAI proteins is a fundamental signaling pathway in T lymphocytes. Conditional deletion of Stim1 and Stim2 genes in T cells abolished SOCE and strongly reduced antibody-mediated immune responses following viral infection ca ...[more]