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Elevated IL-7R? is linked to recurrence and poorer survival of gastric adenocarcinoma.

ABSTRACT: IL-7R? expression has been suggested to be involved in the development of cancer and has been reported to be linked to poor overall survival in patients with lung cancer. However, no evidence has been reportedregarding the significance of IL-7R? expression in gastric adenocarcinoma (GA) untilnow. In the present investigation, to understand the clinicopathological significance of IL-7R? expression in GA, expression of IL-7R? was evaluated using immunohistochemistry in 121 cases of paired GA and its corresponding normal controls. As further confirmation, detection of IL-7R? expression was extended from the protein level to the mRNA level using qRT-PCR. Clinicopathological association was statistically analyzed between IL-7R? expression and clinicopathological variables, including demographic, T classification, clinical stage, lymph nodes metastases, differentiation, recurrence or not, and overall prognosis. IL-7R? expression was markedly up-regulated in GA tissues relative to paired normal controls at both the protein or mRNA level. Elevation of IL-7R? was markedly associated with lymph nodes metastases (P=0.006), differentiation (P=0.005), recurrence (P=0.043), and poor overall prognosis (P=0.039). There were trends toward statistical significance forboth T classification (P=0.063) and clinical stage (P=0.065) despite no significant associations found. Together, our study is the first toanalyze the significance of IL-7R? expression in GA, suggesting its potential predictive value for recurrence and overall prognosis.

SUBMITTER: Jiang H

PROVIDER: S-EPMC6958162 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Elevated IL-7Rα is linked to recurrence and poorer survival of gastric adenocarcinoma.

Jiang Hui H Yang Hao H Wang Hongzhou H Zheng Mei M Liu Baolong B

International journal of clinical and experimental pathology 20180301 3

IL-7Rα expression has been suggested to be involved in the development of cancer and has been reported to be linked to poor overall survival in patients with lung cancer. However, no evidence has been reportedregarding the significance of IL-7Rα expression in gastric adenocarcinoma (GA) untilnow. In the present investigation, to understand the clinicopathological significance of IL-7Rα expression in GA, expression of IL-7Rα was evaluated using immunohistochemistry in 121 cases of paired GA and i ...[more]

PMID: 31938264

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Project description:ImportanceGastric neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma are rare pathological types of gastric cancer, and there is a lack of multicenter studies comparing the prognosis and recurrence patterns of gastric neuroendocrine carcinoma, gastric mixed adenoneuroendocrine carcinoma, and gastric adenocarcinoma.ObjectiveTo compare the differences in long-term survival and patterns of recurrence among gastric neuroendocrine carcinoma, gastric mixed adenoneuroendocrine carcinoma, and gastric adenocarcinoma.Design, setting, and participantsThis cohort study included patients with resectable gastric neuroendocrine carcinoma and gastric mixed adenoneuroendocrine carcinoma at 23 hospitals in China from January 2006 to December 2016. In addition, patients with gastric adenocarcinoma were selected as controls. Propensity score-matched analysis was used to match pathological stage among the different pathological types, and disease-free survival (DFS), postrecurrence survival (PRS), and patterns of recurrence were examined. Data analysis was conducted from July 15, 2020, to October 21, 2020.ExposuresCurative resection for gastric neuroendocrine carcinoma, gastric mixed adenoneuroendocrine carcinoma, and gastric adenocarcinoma.Main outcomes and measuresThe main outcomes were DFS and patterns of recurrence.ResultsA total of 3689 patients were analyzed (median [interquartile range] age, 62 [55-69] years; 2748 [74.5%] men), including 503 patients (13.6%) with gastric neuroendocrine carcinoma, 401 patients (10.9%) with gastric mixed adenoneuroendocrine carcinoma, and 2785 patients (75.5%) with gastric adenocarcinoma. After propensity score matching, 5-year DFS was 47.6% (95% CI, 42.7%-52.5%) for patients with gastric neuroendocrine carcinoma, compared with 57.6% (95% CI, 55.1%-60.1%) with gastric adenocarcinoma (P < .001) and 51.1% (95% CI, 46.0%-56.2%) for patients with gastric mixed adenoneuroendocrine carcinoma, compared with 57.8% (95% CI, 55.1%-60.5%) patients with gastric adenocarcinoma (P = .02). Multivariable analyses found that, compared with gastric adenocarcinoma, gastric neuroendocrine carcinoma (hazard ratio [HR], 1.64; 95% CI, 1.40-1.93) and gastric mixed adenoneuroendocrine carcinoma (HR, 1.25; 95% CI, 1.05-1.49) were independent risk factors associated with worse DFS. Compared with matched patients with gastric adenocarcinoma, patients with gastric neuroendocrine carcinoma were more likely to have distant recurrence (268 patients [17.2%] vs 101 patients [23.7%]; P = .002), as were patients with gastric mixed adenoneuroendocrine carcinoma (232 patients [17.3%] vs 76 patients [22.8%]; P = .02). In multivariate analysis, gastric neuroendocrine carcinoma (HR, 2.22; 95% CI, 1.66-2.98) and gastric mixed adenoneuroendocrine carcinoma (HR, 1.70; 95% CI, 1.24-2.34) were independent risk factors associated with distant recurrence. Additionally, T3 to T4 stage (odds ratio, 2.84; 95% CI, 1.57-5.14; P = .001) and lymph node metastasis (odds ratio, 2.01; 95% CI, 1.31-3.10; P = .002) were independent risk factors associated with distant recurrence of gastric neuroendocrine carcinoma and gastric mixed adenoneuroendocrine carcinoma.Conclusions and relevanceThis cohort study found that patients with gastric neuroendocrine carcinoma or gastric mixed adenoneuroendocrine carcinoma had worse prognoses and were more prone to distant recurrence than those with gastric adenocarcinoma. Thus, different follow-up and treatment strategies should be developed to improve the long-term survival of patients with gastric neuroendocrine carcinoma or gastric mixed adenoneuroendocrine carcinoma, especially patients with tumors penetrating into the subserosa or deeper layers or with lymph node metastasis.

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Elevated IL-7R? is linked to recurrence and poorer survival of gastric adenocarcinoma.

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Elevated IL-7Rα is linked to recurrence and poorer survival of gastric adenocarcinoma.

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