Dataset Information

Differential expression of serine and glycine metabolism-related proteins between follicular neoplasm and Hurthle cell neoplasm.

ABSTRACT: The aim of the study was to investigate the expression of serine/glycine-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and to explore its associated implications. Tissue microarrays were constructed with 265 cases of FN (follicular carcinoma [FC]: 112 and follicular adenoma [FA]: 153) and 107 cases of HCN (Hürthle cell carcinoma [HCC]: 27 and Hürthle cell adenoma [HCA]: 80). The serine/glycine-related proteins PHGDH, PSAT1, SHMT1, and GLDC were evaluated using immunohistochemical staining. The expression of SHMT1 and PHGDH was higher in HCN compared to FN (P<0.001 and P=0.048). SHMT1 expression was highest in HCC, followed by HCA, FA, and FC (P<0.001), and PHGDH expression was highest in HCA, followed by HCC, FC, and FA (P=0.041). In FC, SHMT1 negativity was associated with extrathyroidal extension (P=0.019). In univariate analysis, PSAT1 negativity was associated with shorter overall survival (P<0.001). The expression of serine/glycine-related proteins differed between FN and HCN. The expression of both SHMT1 and PHGDH was higher in HCN compared to FN. The clinical implications of this study are that the serine/glycine metabolism pathway could be a possible therapeutic target in HCC.

SUBMITTER: Kim HM

PROVIDER: S-EPMC6958186 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Differential expression of serine and glycine metabolism-related proteins between follicular neoplasm and Hürthle cell neoplasm.

Kim Hye Min HM Kim Eun-Sol ES Koo Ja Seung JS

International journal of clinical and experimental pathology 20180401 4

The aim of the study was to investigate the expression of serine/glycine-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and to explore its associated implications. Tissue microarrays were constructed with 265 cases of FN (follicular carcinoma [FC]: 112 and follicular adenoma [FA]: 153) and 107 cases of HCN (Hürthle cell carcinoma [HCC]: 27 and Hürthle cell adenoma [HCA]: 80). The serine/glycine-related proteins PHGDH, PSAT1, SHMT1, and GLDC were evaluated using immu ...[more]

PMID: 31938313

Similar Datasets

Project description:Background: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma (HCC) are rare and aggressive thyroid cancers with limited published data comparing their outcomes or regarding their subtypes. The aim of this study was to describe clinicopathological features and compare clinical outcomes of patients with FTC and HCC based on the 2017 World Health Organization definition and extent of vascular invasion (VI). Methods: We retrospectively studied 190 patients with HCC and FTC primarily treated with surgery at Memorial Sloan Kettering Cancer Center between 1986 and 2015. Patients were classified as minimally invasive (MI), encapsulated angioinvasive with focal VI (EA-FVI), encapsulated angioinvasive with extensive VI (EA-EVI), and as widely invasive (WI). To compare clinical outcomes, patients were grouped as follows: group 1 = FTC-MI and FTC EA-FVI, group 2 = FTC EA-EVI and FTC-WI, group 3 = HCC-MI and HCC EA-FVI, group 4 = HCC EA-EVI and HCC-WI. Outcomes of interest were overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), locoregional recurrence-free survival (LRRFS), and distant recurrence-free survival (DRFS). Outcomes were determined using the Kaplan-Meier method and compared with log-rank test. Results: Patients with HCC (n = 111) were more likely to be older than 55 years old (59% vs. 27%, p < 0.001) with a tendency to present with more extensive VI (33% vs. 19%, p = 0.07) compared with FTC (n = 79). Comparing groups 1, 2, 3, and 4, group 4 patients were more likely to recur (DFS 98%, 93%, 98% vs. 73%, respectively, p = 0.0069). There was no statistically significant difference in OS, DSS LRRFS, or DRFS. Stratified by extent of VI (no, focal, and extensive VI), patients with extensive VI were more likely to recur (RFS 100%, 95%, 77%, p = 0.0025) and had poorer distant control (DRFS: 100%, 95%, 80%, p = 0.022), compared with patients absent or focal VI. Conclusions: Accurate assessment of the extent of VI and tumor phenotype (follicular vs. Hurthle) are essential in identifying patients at higher risk of recurrence.

Dataset Information

Differential expression of serine and glycine metabolism-related proteins between follicular neoplasm and Hurthle cell neoplasm.

Publications

Differential expression of serine and glycine metabolism-related proteins between follicular neoplasm and Hürthle cell neoplasm.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets