Ontology highlight
ABSTRACT:
SUBMITTER: Denoel T
PROVIDER: S-EPMC6958493 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Denoël Thibaut T Pedrelli Luca L Pantaleo Giuseppe G Prior John O JO
Pharmaceuticals (Basel, Switzerland) 20191203 4
The immunoreactive fraction <i>r</i> provides important information on the functional purity of radiolabeled proteins. It is traditionally determined by saturating the radioimmunoconjugate with an increasing excess of antigen, followed by linear extrapolation to infinite antigen excess in a double inverse "Lindmo plot". Although several reports have described shortcomings in the Lindmo plot, a systematic examination is lacking. Using an experimental and simulation-based approach, we compared-for ...[more]