Ontology highlight
ABSTRACT:
SUBMITTER: Duan X
PROVIDER: S-EPMC6959240 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Duan Xing X Li Yizeng Y Yi Kexi K Guo Fengli F Wang HaiYang H Wu Pei-Hsun PH Yang Jing J Mair Devin B DB Morales Edwin Angelo EA Kalab Petr P Wirtz Denis D Sun Sean X SX Li Rong R
Nature communications 20200114 1
Migration of meiosis-I (MI) spindle from the cell center to a sub-cortical location is a critical step for mouse oocytes to undergo asymmetric meiotic cell division. In this study, we investigate the mechanism by which formin-2 (FMN2) orchestrates the initial movement of MI spindle. By defining protein domains responsible for targeting FMN2, we show that spindle-periphery localized FMN2 is required for spindle migration. The spindle-peripheral FMN2 nucleates short actin bundles from vesicles der ...[more]