Ontology highlight
ABSTRACT:
SUBMITTER: Hammerling BC
PROVIDER: S-EPMC6959301 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Hammerling Babette C BC Shires Sarah E SE Leon Leonardo J LJ Cortez Melissa Q MQ Gustafsson Åsa B ÅB
Small GTPases 20170918 1
Degradation of mitochondria is an important cellular quality control mechanism mediated by two distinct pathways: one involving Parkin-mediated ubiquitination and the other dependent on mitophagy receptors. It is known that mitochondria are degraded by the autophagy pathway; however, we recently reported that the small GTPase Rab5 and early endosomes also participate in Parkin-mediated mitochondrial clearance. Here, we have developed a protocol to isolate Rab5-positive vesicles from cells for pr ...[more]