Nitrogen-bound diazeniumdiolated amidines.
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ABSTRACT:
SUBMITTER: Biswas D
PROVIDER: S-EPMC6959519 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Nitrogen-bound diazeniumdiolated amidines.
Biswas Debanjan D Deschamps Jeffrey R JR Keefer Larry K LK Hrabie Joseph A JA
Chemical communications (Cambridge, England) 20100630 31
In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs. ...[more]
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