Ontology highlight
ABSTRACT:
SUBMITTER: Dangaj D
PROVIDER: S-EPMC6961655 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Dangaj Denarda D Bruand Marine M Grimm Alizée J AJ Ronet Catherine C Barras David D Duttagupta Priyanka A PA Lanitis Evripidis E Duraiswamy Jaikumar J Tanyi Janos L JL Benencia Fabian F Conejo-Garcia Jose J Ramay Hena R HR Montone Kathleen T KT Powell Daniel J DJ Gimotty Phyllis A PA Facciabene Andrea A Jackson Donald G DG Weber Jeffrey S JS Rodig Scott J SJ Hodi Stephen F SF Kandalaft Lana E LE Irving Melita M Zhang Lin L Foukas Periklis P Rusakiewicz Sylvie S Delorenzi Mauro M Coukos George G
Cancer cell 20190601 6
We investigated the role of chemokines in regulating T cell accumulation in solid tumors. CCL5 and CXCL9 overexpression was associated with CD8<sup>+</sup> T cell infiltration in solid tumors. T cell infiltration required tumor cell-derived CCL5 and was amplified by IFN-γ-inducible, myeloid cell-secreted CXCL9. CCL5 and CXCL9 coexpression revealed immunoreactive tumors with prolonged survival and response to checkpoint blockade. Loss of CCL5 expression in human tumors was associated with epigene ...[more]