Functional validity, role, and implications of heavy alcohol consumption genetic loci.
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SUBMITTER: Thompson A
PROVIDER: S-EPMC6962045 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Functional validity, role, and implications of heavy alcohol consumption genetic loci.
Thompson Andrew A Cook James J Choquet Hélène H Jorgenson Eric E Yin Jie J Kinnunen Tarja T Barclay Jeff J Morris Andrew P AP Pirmohamed Munir M
Science advances 20200115 3
High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Here, we use U.K. Biobank (<i>n</i> = 125,249) and GERA (<i>n</i> = 47,967) datasets to determine genetic factors associated with extreme population-level alcohol consumption and examine the functional validity of outcomes using model organisms and in silico techniques. We identified six loci attaining genome-wide significant association with alcohol cons ...[more]
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