Ontology highlight
ABSTRACT:
SUBMITTER: Aldaz P
PROVIDER: S-EPMC6962164 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Aldaz Paula P Otaegi-Ugartemendia Maddalen M Saenz-Antoñanzas Ander A Garcia-Puga Mikel M Moreno-Valladares Manuel M Flores Juana M JM Gerovska Daniela D Arauzo-Bravo Marcos J MJ Samprón Nicolas N Matheu Ander A Carrasco-Garcia Estefania E
Scientific reports 20200115 1
The developmental regulator SOX9 is linked to cancer progression mainly as a result of its role in the regulation of cancer stem cells (CSCs). However, its activity in the differentiated cells that constitute the heterogeneous tumor bulk has not been extensively studied. In this work, we addressed this aspect in gastric cancer, glioblastoma and pancreatic adenocarcinoma. SOX9 silencing studies revealed that SOX9 is required for cancer cell survival, proliferation and evasion of senescence in vit ...[more]