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Syndecan-3 in Inflammation and Angiogenesis.

ABSTRACT: Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. Roles for this molecule in both neuronal and brain tissue have been identified, and is associated with altered satiety responses. Recent studies suggest that SDC3 expression is not restricted to neuronal tissues and has important roles in inflammatory disorders such as rheumatoid arthritis, disease associated processes such as angiogenesis and in the facilitation of infection of dendritic cells by HIV. The purpose of this review article is to explore these new biological insights into SDC3 functions in inflammatory disease.

SUBMITTER: Arokiasamy S

PROVIDER: S-EPMC6962229 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Syndecan-3 in Inflammation and Angiogenesis.

Arokiasamy Samantha S Balderstone Michaela J M MJM De Rossi Giulia G Whiteford James R JR

Frontiers in immunology 20200109

Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. Roles for this molecule in both neuronal and brain tissue have been identified, and is associated with altered satiety responses. Recent studies suggest th ...[more]

PMID: 31998313

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