Ontology highlight
ABSTRACT:
SUBMITTER: Matsunari H
PROVIDER: S-EPMC6962638 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Stem cell reports 20191226 1
We have previously established a concept of developing exogenic pancreas in a genetically modified pig fetus with an apancreatic trait, thereby proposing the possibility of in vivo generation of functional human organs in xenogenic large animals. In this study, we aimed to demonstrate a further proof-of-concept of the compensation for disabled organogeneses in pig, including pancreatogenesis, nephrogenesis, hepatogenesis, and vasculogenesis. These dysorganogenetic phenotypes could be efficiently ...[more]