Ontology highlight
ABSTRACT:
SUBMITTER: Della Valle F
PROVIDER: S-EPMC6962658 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Della Valle Francesco F Thimma Manjula P MP Caiazzo Massimiliano M Pulcrano Salvatore S Celii Mirko M Adroub Sabir A SA Liu Peng P Alanis-Lobato Gregorio G Broccoli Vania V Orlando Valerio V
Stem cell reports 20200102 1
In mammals, LINE-1 (L1) retrotransposons constitute between 15% and 20% of the genome. Although only a few copies have retained the ability to retrotranspose, evidence in brain and differentiating pluripotent cells indicates that L1 retrotransposition occurs and creates mosaics in normal somatic tissues. The function of de novo insertions remains to be understood. The transdifferentiation of mouse embryonic fibroblasts to dopaminergic neuronal fate provides a suitable model for studying L1 dynam ...[more]