Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC3210333 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Kim Jongpil J Su Susan C SC Wang Haoyi H Cheng Albert W AW Cassady John P JP Lodato Michael A MA Lengner Christopher J CJ Chung Chee-Yeun CY Dawlaty Meelad M MM Tsai Li-Huei LH Jaenisch Rudolf R
Cell stem cell 20111020 5
Recent advances in somatic cell reprogramming have highlighted the plasticity of the somatic epigenome, particularly through demonstrations of direct lineage reprogramming of one somatic cell type to another by defined factors. However, it is not clear to what extent this type of reprogramming is able to generate fully functional differentiated cells. In addition, the activity of the reprogrammed cells in cell transplantation assays, such as those envisaged for cell-based therapy of Parkinson's ...[more]