Ontology highlight
ABSTRACT:
SUBMITTER: Sitron CS
PROVIDER: S-EPMC6964901 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Sitron Cole S CS Park Joseph H JH Giafaglione Jenna M JM Brandman Onn O
PloS one 20200116 1
The Ribosome-associated Quality Control (RQC) pathway co-translationally marks incomplete polypeptides from stalled translation with two signals that trigger their proteasome-mediated degradation. The E3 ligase Ltn1 adds ubiquitin and Rqc2 directs the large ribosomal subunit to append carboxy-terminal alanine and threonine residues (CAT tails). When excessive amounts of incomplete polypeptides evade Ltn1, CAT-tailed proteins accumulate and can self-associate into aggregates. CAT tail aggregation ...[more]