Ontology highlight
ABSTRACT:
SUBMITTER: Plateau P
PROVIDER: S-EPMC5355996 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Plateau Pierre P Saveanu Cosmin C Lestini Roxane R Dauplais Marc M Decourty Laurence L Jacquier Alain A Blanquet Sylvain S Lazard Myriam M
Scientific reports 20170317
Selenomethionine, a dietary supplement with beneficial health effects, becomes toxic if taken in excess. To gain insight into the mechanisms of action of selenomethionine, we screened a collection of ≈5900 Saccharomyces cerevisiae mutants for sensitivity or resistance to growth-limiting amounts of the compound. Genes involved in protein degradation and synthesis were enriched in the obtained datasets, suggesting that selenomethionine causes a proteotoxic stress. We demonstrate that selenomethion ...[more]