Ontology highlight
ABSTRACT:
SUBMITTER: Lin YJ
PROVIDER: S-EPMC6965081 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lin Yu-Ju YJ Wen Chiao-Ni CN Lin Ying-Ying YY Hsieh Wen-Chi WC Chang Chia-Chen CC Chen Yi-Hsuan YH Hsu Chian-Hui CH Shih Yun-Jui YJ Chen Chang-Hsun CH Fang Chi-Tai CT
Nature communications 20200116 1
Standard inactivated influenza vaccines are poorly immunogenic in immunologically naive healthy young children, who are particularly vulnerable to complications from influenza. For them, there is an unmet need for better influenza vaccines. Oil-in-water emulsion-adjuvanted influenza vaccines are promising candidates, but clinical trials yielded inconsistent results. Here, we meta-analyze randomized controlled trials with efficacy data (3 trials, n = 15,310) and immunogenicity data (17 trials, n ...[more]