Ontology highlight
ABSTRACT:
SUBMITTER: Dahiya S
PROVIDER: S-EPMC6965082 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20200116 1
Foxp3<sup>+</sup> T-regulatory (Treg) cells are capable of suppressing immune responses. Lysine acetylation is a key mechanism of post-translational control of various transcription factors, and when acetylated, Foxp3 is stabilized and transcriptionally active. Therefore, understanding the roles of various histone/protein deacetylases (HDAC) are key to promoting Treg-based immunotherapy. Several of the 11 classical HDAC enzymes are necessary for optimal Treg function while others are dispensable ...[more]