Ontology highlight
ABSTRACT:
SUBMITTER: Kim JY
PROVIDER: S-EPMC6965100 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kim Ji Young JY Kim Kyu Min KM Yang Ji Hye JH Cho Sam Seok SS Kim Seung Jung SJ Park Su Jung SJ Ahn Sang-Gun SG Lee Gum Hwa GH Yang Jin Won JW Lim Sung Chul SC Kang Keon Wook KW Ki Sung Hwan SH
Scientific reports 20200116 1
Hepatic stellate cells (HSCs) are essential for liver fibrosis. E6 associated protein (E6AP) is one of the E3-ubiquitin-protein ligase and has been studied in proliferation and cellular stress. Currently, no information is available on the role of E6AP on transforming growth factor-β (TGF-β) signaling and hepatic fibrogenesis. This study examined whether E6AP is overexpressed in activated HSCs, and if so, its effect on hepatic fibrogenesis and the molecular mechanism. E6AP was expressed higher i ...[more]