Ontology highlight
ABSTRACT:
SUBMITTER: Mielczarek-Lewandowska A
PROVIDER: S-EPMC6965345 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Apoptosis : an international journal on programmed cell death 20200201 1-2
HSP90 (heat shock protein 90) is an ATP-dependent molecular chaperone involved in a proper folding and maturation of hundreds of proteins. HSP90 is abundantly expressed in cancer, including melanoma. HSP90 client proteins are the key oncoproteins of several signaling pathways controlling melanoma development, progression and response to therapy. A number of natural and synthetic compounds of different chemical structures and binding sites within HSP90 have been identified as selective HSP90 inhi ...[more]