Dataset Information

PhosphoCETSA - Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors

ABSTRACT: The goal of this project is to study the mechanisms of resistance to Hsp90i using phosphoCETSA-MS

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Gianluca Maddalo

LAB HEAD: Mathias Uhlen

PROVIDER: PXD005547 | Pride | 2018-02-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	HF1_20160218_GM_SKMel24_Ph_CETSA_DMSO1_1.raw	Raw
	HF1_20160218_GM_SKMel24_Ph_CETSA_DMSO1_2.raw	Raw
	HF1_20160218_GM_SKMel24_Ph_CETSA_DMSO2_1.raw	Raw
	HF1_20160218_GM_SKMel24_Ph_CETSA_DMSO2_2.raw	Raw
	HF1_20160218_GM_SKMel24_Ph_CETSA_XL1_1.raw	Raw

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Publications

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

Azimi Alireza A Caramuta Stefano S Seashore-Ludlow Brinton B Boström Johan J Robinson Jonathan L JL Edfors Fredrik F Tuominen Rainer R Kemper Kristel K Krijgsman Oscar O Peeper Daniel S DS Nielsen Jens J Hansson Johan J Egyhazi Brage Suzanne S Altun Mikael M Uhlen Mathias M Maddalo Gianluca G

Molecular systems biology 20180305 3

Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of therapy-resistant melanomas. Unfortunately, our data show that this combination elicits a heterogeneous response in a panel of melanoma cell lines including PDX-derived models. We sought to understand the mechanisms underlying the differential responses and suggest a patient stratification strategy. Thermal proteome profiling (TPP) identified the prote ...[more]

PMID: 29507054

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