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High expression of NME1 correlates with progression and poor prognosis in patients of hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common malignancies that results from genes regulation via different pathways. NME/NM23 nucleoside diphosphate kinase 1 (NME1) is generally regarded as a metastasis suppressor, but its function in HCC is largely unknown. In our study, we explored the role of NME1 in HCC. By analyzing the gene expression omnibus (GEO) database, we discovered that NME1 was more highly expressed in HCC tumor tissues than non-HCC liver tissues (P < 0.001), and NME1 was significantly up-regulated in HCC tumor tissues than in adjacent normal tissues (P < 0.001). Then, validated by the enrolled HCC patients and The Cancer Genome Atlas (TCGA) database, NME1 was upregulated in HCC tumor tissues compared with matched adjacent normal tissue (P < 0.05). Besides, NME1 was down-regulated in Stage III/IV HCC patients than Stage I/II HCC patients (P = 0.009). Moreover, Kaplan-Meier analysis showed that HCC patients with high NME1 expression had poor overall survival (P = 0.004) and higher recurrence rate (P < 0.001). Our data revealed that NME1 was a special oncogene, and its expression was significantly associated with the progression and prognosis of HCC. NME1 may be a novel molecular biomarker for the targeted therapy and prognosis of HCC.

SUBMITTER: Yang J

PROVIDER: S-EPMC6965413 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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High expression of NME1 correlates with progression and poor prognosis in patients of hepatocellular carcinoma.

Yang Jie J Lv Zhihua Z Huang Jingtao J Zhao Yi Y Li Yan Y

International journal of clinical and experimental pathology 20170801 8

Hepatocellular carcinoma (HCC) is one of the most common malignancies that results from genes regulation via different pathways. NME/NM23 nucleoside diphosphate kinase 1 (NME1) is generally regarded as a metastasis suppressor, but its function in HCC is largely unknown. In our study, we explored the role of NME1 in HCC. By analyzing the gene expression omnibus (GEO) database, we discovered that NME1 was more highly expressed in HCC tumor tissues than non-HCC liver tissues (P ...[more]

PMID: 31966710

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Project description:Hepatocellular carcinoma (HCC) is a common malignant tumor in the clinic. Although there are increasing numbers of available treatment methods, their therapeutic effects are not satisfactory. The clinical indicators commonly used to predict the prognosis of HCC include tumor size, degree of cirrhosis, degree of tumor differentiation and tumor microvascular invasion; however, there are currently no molecular indicators that can predict the prognosis of HCC. Due to the differences in the progression of liver cancer among individuals, there is a growing need for prognostic biomarkers to accurately stratify patients for appropriate risk-adaptive treatment. The DNA topoisomerase 2-? (TOP2A) gene, which is located on human chromosome 17, encodes DNA topoisomerase II?. Previous studies have demonstrated that TOP2A indicates a poor prognosis in patients with various types of tumors, but no such studies are currently available on HCC. By analyzing the differential expression of TOP2A in 50 pairs of tumor and paracancerous tissue samples in The Cancer Genome Atlas (TCGA) database, the present study revealed that the expression of TOP2A was significantly higher in tumor tissue compared with that in paracancerous tissue (P=6.319×10-16). In the collected clinical samples, the mRNA expression levels of TOP2A were significantly upregulated in HCC tumor tissues compared with those in the paracancerous tissues (P=6.40×10-3), suggesting that TOP2A was associated with the occurrence and development of liver cancer. In addition, the associations between TOP2A expression, clinicopathological features and prognosis were analyzed using a multi-center large sample dataset from TCGA database, and the results demonstrated that high expression of TOP2A was associated with a higher T stage, poorer clinical stage and higher histological grade compared with those in patients with low TOP2A expression. High expression of TOP2A was also identified to be associated with a poor prognosis of HCC, particularly in Asian populations. These results suggested that high expression of TOP2A in HCC tissues may be closely associated with tumor progression and metastasis, which may be used as a biological indicator to predict tumor prognosis in clinical practice.

Dataset Information

High expression of NME1 correlates with progression and poor prognosis in patients of hepatocellular carcinoma.

Publications

High expression of NME1 correlates with progression and poor prognosis in patients of hepatocellular carcinoma.

Similar Datasets

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