Ontology highlight
ABSTRACT:
SUBMITTER: Hirpara JL
PROVIDER: S-EPMC6965745 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hirpara Jayshree L JL Subramaniam Kothandharaman K Bellot Gregory G Qu Jianhua J Seah Serena S Loh Thomas T Tucker-Kellogg Lisa L Clement Marie-Veronique MV Pervaiz Shazib S
Redox biology 20191216
The death inhibitory proteins, cFLIP and Bcl-2, canonically act at different steps to regulate receptor-mediated apoptosis in cancer cells. Here we report that pharmacological or genetic means to effect an increase in intracellular superoxide result in cFLIP upregulation. Interestingly, Bcl-2 overexpression is associated with a concomitant increase in cFLIP, and reducing superoxide sensitizes Bcl-2 overexpressing cancer cells to receptor-mediated apoptosis via downregulation of cFLIP. Moreover, ...[more]