Dataset Information

Association between ACE gene polymorphisms and Alzheimer's disease in Han population in Hebei Peninsula.

ABSTRACT: PURPOSE:This study aimed to detect the association between angiotensin I converting enzyme (ACE) gene polymorphisms (rs4343 and rs1800764) and Alzheimer's disease (AD) in Han population in Hebei Peninsular. METHODS:We recruited 113 AD patients and 142 healthy individuals in this case-control study. Differences of genotypes, alleles and haplotypes in two groups were analyzed by chi-square test. Besides, odds ratios (ORs) and 95% confidence intervals (CIs) were used to represent the relative risk of AD. At last, the analyses of linkage disequilibrium and haplotypes were done with HaploView software. RESULTS:In the analyses of genotypes and alleles of ACE polymorphisms (rs4343 and rs1800764) in AD, no obvious association was found between genotypes and alleles of rs4343 with the susceptibility of AD. In rs1800764 polymorphism, only C allele had significant association with AD susceptibility (P=0.035, OR=1.473, 95% CI=1.027-2.111), which suggested that rs1800764 C allele is the susceptible allele of AD. Linkage disequilibrium analysis between rs4343 and rs1800764 polymorphisms indicated there existed 3 haplotypes (A-T, A-C and G-C). A-C haplotype might associate with the susceptibility of AD (P=0.023, OR=2.591, 95% CI=1.111-6.043). CONCLUSION:Rs4343 polymorphism of ACE gene had no relationship with AD risk. C allele of rs1800764 could increase the susceptibility of AD. A-C haplotype of rs4343 and rs1800764 polymorphisms might increase the risk of AD, and the ORs was 2.591.

SUBMITTER: Wang X

PROVIDER: S-EPMC6965948 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Association between <i>ACE</i> gene polymorphisms and Alzheimer's disease in Han population in Hebei Peninsula.

Wang Xiaoli X Zhang Fengchun F Cui Yongjian Y Zheng Lei L Wei Yan Y

International journal of clinical and experimental pathology 20170901 9

<h4>Purpose</h4>This study aimed to detect the association between angiotensin I converting enzyme (<i>ACE</i>) gene polymorphisms (rs4343 and rs1800764) and Alzheimer's disease (AD) in Han population in Hebei Peninsular.<h4>Methods</h4>We recruited 113 AD patients and 142 healthy individuals in this case-control study. Differences of genotypes, alleles and haplotypes in two groups were analyzed by chi-square test. Besides, odds ratios (ORs) and 95% confidence intervals (CIs) were used to repres ...[more]

PMID: 31966905

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Project description:AimsAlzheimer's disease (AD) is a multifactor disease that has been reported to have a close association with type 2 diabetes (T2D) where the v-akt murine thymoma viral oncogene homolog 1 (AKT1) plays an important role in the protein synthesis pathways and cell apoptosis processes. Evidence has been shown that AKT1 protein may be related to AD risk among patients with T2D. The aim of this study was to analyze the potential association between single nucleotide polymorphisms of AKT1 promoter and the risk of AD among patients with T2D.MethodsThe association between AKT1 polymorphisms and AD risk in patients with T2D was assessed among 574 consecutive unrelated subjects including 112 AD patients with T2D, 231 patients with AD, and 231 healthy controls in a case-control study. The cognitive function of all subjects was assessed using MMSE. Six single nucleotide polymorphisms with minor allele frequency >0.2 (rs2498786, rs74090038, rs2494750, rs2494751, rs5811155, and rs2494752) in AKT1 promoter were analyzed by polymerase chain reaction (PCR), and the concentration of AKT1 protein in serum was tested using enzyme-linked immunosorbent assay (ELISA).ResultsOverall, there was statistically significant difference in AKT1 rs2498786 polymorphism. The CC frequency of AKT1 rs2498786 polymorphism in AD with T2D group and AD control group was significantly higher than that in healthy control group (PAD+T2D vs. health < 0.0001, PAD vs. health < 0.0001). However, the difference was not found between AD with T2D group and AD control group. Compared with healthy control group, the plasma levels of AKT1 protein in AD with T2D group (PAD+T2D vs. health < 0.0001) and AD control group (PAD vs. health = 0.0003) decreased significantly. Among genotypes of AKT1 rs2498786 polymorphism, the AKT1 protein level in GG genotype was significantly higher than that in GC genotype (PGG vs. GC < 0.0001) and CC genotype (PGG vs. CC < 0.0001).ConclusionThe study suggests that AKT1 rs2498786 polymorphism in insulin signaling pathway may be associated with AD risk and different genotypes may affects levels of protein expression. However, the polymorphism is not shown to be exclusive in AD patients with T2D.

Dataset Information

Association between ACE gene polymorphisms and Alzheimer's disease in Han population in Hebei Peninsula.

Publications

Association between <i>ACE</i> gene polymorphisms and Alzheimer's disease in Han population in Hebei Peninsula.

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