Ontology highlight
ABSTRACT:
SUBMITTER: Wu WY
PROVIDER: S-EPMC6966482 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wu Wendy Yi-Ying WY Johansson Gunnar G Wibom Carl C Brännström Thomas T Malmström Annika A Henriksson Roger R Golovleva Irina I Bondy Melissa L ML Andersson Ulrika U Dahlin Anna M AM Melin Beatrice B
Cancers 20191212 12
Genome-wide association studies have identified 25 germline genetic loci that increase the risk of glioma. The somatic tumor molecular alterations, including <i>IDH</i>-mutation status and 1p/19q co-deletion, have been included into the WHO 2016 classification system for glioma. To investigate how the germline genetic risk variants correlate with the somatic molecular subtypes put forward by WHO, we performed a meta-analysis that combined findings from 330 Swedish cases and 876 controls with two ...[more]