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Racial Differences in Immunological Landscape Modifiers Contributing to Disparity in Prostate Cancer.

ABSTRACT: Prostate cancer affects African Americans disproportionately by exhibiting greater incidence, rapid disease progression, and higher mortality when compared to their Caucasian counterparts. Additionally, standard treatment interventions do not achieve similar outcome in African Americans compared to Caucasian Americans, indicating differences in host factors contributing to racial disparity. African Americans have allelic variants and hyper-expression of genes that often lead to an immunosuppressive tumor microenvironment, possibly contributing to more aggressive tumors and poorer disease and therapeutic outcomes than Caucasians. In this review, we have discussed race-specific differences in external factors impacting internal milieu, which modify immunological topography as well as contribute to disparity in prostate cancer.

SUBMITTER: King Thomas J

PROVIDER: S-EPMC6966521 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Racial Differences in Immunological Landscape Modifiers Contributing to Disparity in Prostate Cancer.

King Thomas Jeronay J Mir Hina H Kapur Neeraj N Singh Shailesh S

Cancers 20191125 12

Prostate cancer affects African Americans disproportionately by exhibiting greater incidence, rapid disease progression, and higher mortality when compared to their Caucasian counterparts. Additionally, standard treatment interventions do not achieve similar outcome in African Americans compared to Caucasian Americans, indicating differences in host factors contributing to racial disparity. African Americans have allelic variants and hyper-expression of genes that often lead to an immunosuppress ...[more]

PMID: 31769418

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