Ontology highlight
ABSTRACT:
SUBMITTER: Shi X
PROVIDER: S-EPMC6968515 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Shi Xiaodong X Shao Tihong T Huo Feifei F Zheng Chenqing C Li Wanyu W Jiang Zhenyu Z
PeerJ 20200114
Systemic sclerosis is a chronic multisystem autoimmune disease that is associated with polyclonal B cell hyperreactivity. The CDR3 of BCRs is the major site of antigen recognition. Therefore, we analyzed the BCR repertoire of patients with SSc. The BCR repertoires in 12 subjects including eight SSc patients and four healthy controls were characterized by high-throughput sequencing, and bioinformatics analysis were studied. The average CDR3 length in the SSc group was significantly shorter. The S ...[more]