Ontology highlight
ABSTRACT:
SUBMITTER: Palit SA
PROVIDER: S-EPMC6968917 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Palit Sander Al SA Vis Daniel D Stelloo Suzan S Lieftink Cor C Prekovic Stefan S Bekers Elise E Hofland Ingrid I Šuštić Tonći T Wolters Liesanne L Beijersbergen Roderick R Bergman Andries M AM Győrffy Balázs B Wessels Lodewyk Fa LF Zwart Wilbert W van der Heijden Michiel S MS
eLife 20191219
Androgen receptor (AR) inhibitors represent the mainstay of prostate cancer treatment. In a genome-wide CRISPR-Cas9 screen using LNCaP prostate cancer cells, loss of co-repressor <i>TLE3</i> conferred resistance to AR antagonists apalutamide and enzalutamide. Genes differentially expressed upon <i>TLE3</i> loss share AR as the top transcriptional regulator, and <i>TLE3</i> loss rescued the expression of a subset of androgen-responsive genes upon enzalutamide treatment. GR expression was strongly ...[more]