Ontology highlight
ABSTRACT:
SUBMITTER: Singh K
PROVIDER: S-EPMC6969214 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Singh Kanika K Gupta Ankit A Sarkar Ashish A Gupta Ishita I Rana Santanu S Sarkar Sagartirtha S Khan Sameena S
Scientific reports 20200117 1
Myocardial hypertrophy, an inflammatory condition of cardiac muscles is a maladaptive response of the heart to biomechanical stress, hemodynamic or neurohormonal stimuli. Previous studies indicated that knockout of Arginyltransferase (ATE1) gene in mice and embryos leads to contractile dysfunction, defective cardiovascular development, and impaired angiogenesis. Here we found that in adult rat model, downregulation of ATE1 mitigates cardiac hypertrophic, cardiac fibrosis as well as apoptosis res ...[more]