Ontology highlight
ABSTRACT:
SUBMITTER: Guo S
PROVIDER: S-EPMC7085222 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Guo Sen S Liu Yuan Y Gao Lu L Xiao Fankai F Shen Jihong J Xing Shiying S Yang Fan F Zhang Wencai W Shi Qiangwei Q Li Yan Y Zhao Luosha L
International journal of biological sciences 20200221 8
Cardiac remodeling is a major early event of heart failure, which is regulated by multiple signaling pathways. Here, we demonstrate that TBC1D25 is upregulated during pathological cardiac remodeling. The aim of this study is to determine the role of TBC1D25 in cardiac remodeling and to illustrate the underlying molecular mechanism. Specifically, cardiac remodeling was induced in TBC1D25-KO mice and their wild-type control mice through partial transverse aortic constriction (TAC) of aortic arch. ...[more]