Ontology highlight
ABSTRACT:
SUBMITTER: Vashistha N
PROVIDER: S-EPMC4889393 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Vashistha Nidhi N Neal Sonya E SE Singh Amanjot A Carroll Sarah M SM Hampton Randolph Y RY
Proceedings of the National Academy of Sciences of the United States of America 20160511 21
The HRD (HMG-CoA reductase degradation) pathway is a conserved route of endoplasmic reticulum-associated degradation (ERAD), by which misfolded ER proteins are ubiquitinated and degraded. ERAD substrates are ubiquitinated by the action of the Hrd1 RING-H2 E3 ligase. Hrd1 is always present in a stoichiometric complex with the ER membrane protein Hrd3, which is also required for HRD-dependent degradation. Despite its conserved presence, unequivocal study of Hrd3 function has been precluded by its ...[more]