Ontology highlight
ABSTRACT:
SUBMITTER: Minderjahn J
PROVIDER: S-EPMC6972792 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Minderjahn Julia J Schmidt Andreas A Fuchs Andreas A Schill Rudolf R Raithel Johanna J Babina Magda M Schmidl Christian C Gebhard Claudia C Schmidhofer Sandra S Mendes Karina K Ratermann Anna A Glatz Dagmar D Nützel Margit M Edinger Matthias M Hoffmann Petra P Spang Rainer R Längst Gernot G Imhof Axel A Rehli Michael M
Nature communications 20200121 1
Establishing gene regulatory networks during differentiation or reprogramming requires master or pioneer transcription factors (TFs) such as PU.1, a prototype master TF of hematopoietic lineage differentiation. To systematically determine molecular features that control its activity, here we analyze DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression. Although PU.1, in contrast to classical pioneer factors, is unable to access nucleosom ...[more]