Ontology highlight
ABSTRACT:
SUBMITTER: Huang Z
PROVIDER: S-EPMC6972855 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Huang Zhengyan Z Lane Andrew N AN Fan Teresa W-M TW Higashi Richard M RM Weiss Heidi L HL Yin Xiangrong X Wang Chi C
Scientific reports 20200121 1
Mass spectrometry (MS) is frequently used for proteomic and metabolomic profiling of biological samples. Data obtained by MS are often zero-inflated. Those zero values are called point mass values (PMVs). Zero values can be further grouped into biological PMVs and technical PMVs. The former type is caused by true absence of a compound and the later type is caused by a technical detection limit. Methods based on a mixture model have been developed to separate the two types of zeros and to perform ...[more]