Ontology highlight
ABSTRACT:
SUBMITTER: Peng X
PROVIDER: S-EPMC6109378 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Peng Xiaoling X Li Gang G Liu Zhenqiu Z
Journal of computational biology : a journal of computational molecular cell biology 20151216 2
Metagenomics data have been growing rapidly due to the advances in NGS technologies. One goal of human microbial studies is to detect abundance differences across clinical conditions. Besides small sample size and high dimension, metagenomics data are usually represented as compositions (proportions) with a large number of zeros and skewed distribution. Efficient tools for handling such compositional data need to be developed. We propose a zero-inflated beta regression approach (ZIBSeq) for iden ...[more]