Ontology highlight
ABSTRACT:
SUBMITTER: Imberti C
PROVIDER: S-EPMC6973108 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Imberti Cinzia C Zhang Pingyu P Huang Huaiyi H Sadler Peter J PJ
Angewandte Chemie (International ed. in English) 20190924 1
In this Minireview, we highlight recent advances in the design of transition metal complexes for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the challenges and opportunities for the translation of such agents into clinical use. New designs for light-activated transition metal complexes offer photoactivatable prodrugs with novel targeted mechanisms of action. Light irradiation can provide spatial and temporal control of drug activation, increasing selectivity an ...[more]