Unknown

Dataset Information

0

BST2 regulates interferon gamma-dependent decrease in invasion of HTR-8/SVneo cells via STAT1 and AKT signaling pathways and expression of E-cadherin.


ABSTRACT: The mechanism by which interferon-gamma (IFN-γ) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-γ led to a decrease in their invasion concomitant with an increased expression of BST2. Silencing of BST2 by siRNA showed a significant increase in their invasion and spreading after treatment with IFN-γ as well as downregulated expression of E-cadherin. Further, STAT1 silencing inhibited the IFN-γ-dependent increase in the expression of BST2 and E-cadherin. Treatment of HTR-8/SVneo cells with IFN-γ led to the activation of AKT, and its inhibition with PI3K inhibitor abrogated IFN-γ-mediated decrease in invasion/spreading and downregulated BST2 and E-cadherin expression. Collectively, IFN-γ decreases the invasion of HTR-8/SVneo cells by STAT1 and AKT activation via increased expression of BST2 and E-cadherin.

SUBMITTER: Verma S 

PROVIDER: S-EPMC6973314 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6363024 | biostudies-literature
| S-EPMC5833820 | biostudies-other
| S-EPMC5444796 | biostudies-literature
| S-EPMC8060792 | biostudies-literature
| S-EPMC6946778 | biostudies-literature
| S-EPMC1592099 | biostudies-literature
| S-EPMC6350042 | biostudies-literature
| S-EPMC8063148 | biostudies-literature
| S-EPMC3911376 | biostudies-literature
| S-EPMC5415790 | biostudies-literature