Ontology highlight
ABSTRACT:
SUBMITTER: Medlock GL
PROVIDER: S-EPMC6975163 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Medlock Gregory L GL Papin Jason A JA
Cell systems 20200108 1
Mechanistic models explicitly represent hypothesized biological knowledge. As such, they offer more generalizability than data-driven models. However, identifying model curation efforts that improve performance for mechanistic models is nontrivial. Here, we develop a solution to this problem for genome-scale metabolic models. We generate an ensemble of models, each equally consistent with experimental data, then perform simulations with them. We apply machine learning to the simulation output to ...[more]